| Primary Identifier | MGI:2135607 | Organism | mouse, laboratory |
| Chromosome | 10 | NCBI Gene Number | 93759 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables several functions, including NAD-dependent protein lysine deacylase activity; p53 binding activity; and transcription coregulator activity. Involved in several processes, including regulation of biosynthetic process; regulation of fat cell differentiation; and regulation of intracellular signal transduction. Acts upstream of or within several processes, including behavioral response to starvation; cellular response to leukemia inhibitory factor; and negative regulation of macromolecule biosynthetic process. Located in heterochromatin; mitochondrion; and nucleus. Part of protein-containing complex. Is expressed in several structures, including brain; gonad; heart; metanephros; and sensory organ. Used to study nephrogenic diabetes insipidus and steatotic liver disease. Human ortholog(s) of this gene implicated in Huntington's disease and prostate cancer. Orthologous to human SIRT1 (sirtuin 1). PHENOTYPE: Mice homozygous for a knock-out allele show embryonic and fetal lethality, abnormal embryogenesis, and abnormal cellular phenotypes of derived MEFs. Mice homozygous for other knock-out alleles may exhibit peri- and postnatal lethality and heart, mammary gland, eye, and reproductive system anomalies. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
