| Primary Identifier | MGI:95780 | Organism | mouse, laboratory |
| Chromosome | 10 | NCBI Gene Number | 14687 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables adenylate cyclase inhibitor activity. Involved in negative regulation of insulin secretion. Acts upstream of or within G protein-coupled serotonin receptor signaling pathway. Located in cell body and dendrite. Is active in plasma membrane and synapse. Is expressed in early conceptus; early tubule; gonad; and nervous system. Orthologous to human GNAZ (G protein subunit alpha z). PHENOTYPE: Mice homozygous for a knock-out allele exhibit hypertolerance to morphine. Mice homozygous for a reporter allele exhibit impaired platelet aggregation, increased resistance to fatal thromboembolism, reduced morphine-elicited antinociception, and altered behavioral responses to addictive substances. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
