| Primary Identifier | MGI:1859287 | Organism | mouse, laboratory |
| Chromosome | 10 | NCBI Gene Number | 54427 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables enzyme activator activity. Involved in several processes, including epigenetic regulation of gene expression; male meiosis I; and negative regulation of DNA methylation-dependent heterochromatin formation. Acts upstream of or within several processes, including chorionic trophoblast cell differentiation; epigenetic regulation of gene expression; and placenta development. Located in condensed nuclear chromosome; cytoplasm; and heterochromatin. Part of ESC/E(Z) complex. Is expressed in several structures, including alimentary system; brain; early conceptus; gonad; and sensory organ. Orthologous to human DNMT3L (DNA methyltransferase 3 like). PHENOTYPE: Mutants in this imprinted gene lack appropriate methylation of the maternal allele and this, in turn, causes azoospermia in homozygous males; and heterozygous progeny of homozygous females die by midgestation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
