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Protein Coding Gene : Icosl icos ligand
Primary Identifier  MGI:1354701 Organism  mouse, laboratory
Chromosome  10 NCBI Gene Number  50723
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Predicted to enable identical protein binding activity and signaling receptor binding activity. Involved in positive regulation of interleukin-4 production. Located in external side of plasma membrane. Is expressed in several structures, including extraembryonic component; gonad; hemolymphoid system gland; liver; and stomach. Orthologous to human ICOSLG (inducible T cell costimulator ligand).
PHENOTYPE: Mice homozygous for disruptions in this gene exhibit defects in the humoral immune response associated with an impaired interactions between T and B cells. [provided by MGI curators]
  • synonyms:
  • Icosl,
  • B7h,
  • LICOS,
  • GL50,
  • AU044799,
  • GL50-B,
  • expressed sequence AU044799,
  • EST BG071784,
  • B7-H2,
  • BG071784,
  • B7RP-1,
  • icos ligand,
  • ICOS-L,
  • MGI:2143770,
  • MGI:2652130
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4 Involved In Mutations

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0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

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Canonical gene --> Transcripts in specific strains.

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Genes --> Homologs

Interactions

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Gene --> Protein-Protein Interactions

Expression

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Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

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