Primary Identifier | MGI:106618 | Organism | mouse, laboratory |
Chromosome | 10 | NCBI Gene Number | 110012 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables microtubule binding activity and tubulin-glutamic acid ligase activity. Acts upstream of or within several processes, including adult behavior; protein polyglutamylation; and sperm axoneme assembly. Predicted to be located in centrosome and membrane. Predicted to be active in microtubule organizing center. Orthologous to human TPGS1 (tubulin polyglutamylase complex subunit 1). PHENOTYPE: Male mice homozygous for a gene trapped allele are sterile due to abnormal development of the spermatid flagellum. Adult males display a striking deficit in intermale aggression and reduced body fat, not due to an altered resting metabolic rate or hypophagia. [provided by MGI curators] |