| Primary Identifier | MGI:87931 | Organism | mouse, laboratory |
| Chromosome | 10 | NCBI Gene Number | 11537 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable serine-type endopeptidase activity. Acts upstream of or within several processes, including complement activation, alternative pathway; retina development in camera-type eye; and vascular associated smooth muscle cell differentiation. Located in extracellular space. Is expressed in adipose tissue; brown fat; epididymal fat pad; and white fat. Orthologous to human CFD (complement factor D). PHENOTYPE: Mice homozygous for a knock-out allele show impaired complement activation by alternative pathway activators, and increased susceptibility to pneumococcal infection. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
