Primary Identifier | MGI:893588 | Organism | mouse, laboratory |
Chromosome | 10 | NCBI Gene Number | 12696 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables poly(U) RNA binding activity and translation repressor activity. Involved in stress granule assembly. Acts upstream of or within cellular response to cold; negative regulation of cell growth; and regulation of cell cycle G1/S phase transition. Located in cytoplasmic stress granule and nucleoplasm. Is expressed in several structures, including central nervous system; olfactory epithelium; and retina. Orthologous to human CIRBP (cold inducible RNA binding protein). PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired spermatogonia proliferation. [provided by MGI curators] |