| Primary Identifier | MGI:97514 | Organism | mouse, laboratory |
| Chromosome | 10 | NCBI Gene Number | 18551 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable serine-type endopeptidase activity. Involved in fertilization and sperm capacitation. Acts upstream of or within acrosome reaction and binding activity of sperm to zona pellucida. Located in acrosomal membrane. Is expressed in early conceptus; epididymis; gonad; and neural retina. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma. Orthologous to human PCSK4 (proprotein convertase subtilisin/kexin type 4). PHENOTYPE: Mice homozygous for a knock-out allele show reduced male fertility, accelerated sperm capacitation, precocious acrosome reaction, reduced binding of sperm to egg zona pellucida, impaired fertilization, and abnormalities in sperm head/acrosome formation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
