| Primary Identifier | MGI:88006 | Organism | mouse, laboratory |
| Chromosome | 10 | NCBI Gene Number | 11705 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable type II transforming growth factor beta receptor binding activity. Involved in gonad development; negative regulation of ovarian follicle development; and sex determination. Located in cytoplasm. Is expressed in several structures, including aorta-gonad-mesonephros; genitourinary system; liver; lung; and spleen. Human ortholog(s) of this gene implicated in disorder of sexual development; ovarian carcinoma; and persistent Mullerian duct syndrome. Orthologous to human AMH (anti-Mullerian hormone). PHENOTYPE: Homozygous null mutant males have a complete male reproductive tract and functional sperm, but also uterus and oviducts. Most are infertile due to female organs blocking sperm transfer. Females are fertile with enlarged ovaries and atypical follicles. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
