| Primary Identifier | MGI:2384786 | Organism | mouse, laboratory |
| Chromosome | 10 | NCBI Gene Number | 208677 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein dimerization activity. Involved in positive regulation of transcription by RNA polymerase II and response to endoplasmic reticulum stress. Located in membrane and nucleus. Is expressed in several structures, including extraembryonic visceral endoderm; genitourinary system; gut; liver; and septum transversum. Orthologous to human CREB3L3 (cAMP responsive element binding protein 3 like 3). PHENOTYPE: Mice homozygous for a knock-out allele are viable and healthy but exhibit reduced expression of acute phase response proteins following treatment with tunicamycin that induces ER stress. Mice homozygous for a different knock-out allele exhibit resistanceto sulpyrine-induced shock. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
