| Primary Identifier | MGI:98496 | Organism | mouse, laboratory |
| Chromosome | 10 | NCBI Gene Number | 21390 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables thromboxane receptor activity. Acts upstream of or within several processes, including positive regulation of smooth muscle contraction; regulation of vasoconstriction; and response to lipopolysaccharide. Predicted to be located in acrosomal vesicle and nuclear speck. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Human ortholog(s) of this gene implicated in aspirin-induced respiratory disease; asthma; and blood platelet disease. Orthologous to human TBXA2R (thromboxane A2 receptor). PHENOTYPE: Homozygotes for a null allele show prolonged bleeding, and altered platelet aggregation and vascular responses to TXA2, arachidonic acid and injury. Homozygotes for another null allele show splenomegaly, reduced DC-T cell adhesion, enhanced contact hypersensitivity, and cervical lymphadenopathy. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
