Primary Identifier | MGI:95806 | Organism | mouse, laboratory |
Chromosome | 10 | NCBI Gene Number | 14797 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables transcription corepressor activity. Acts upstream of or within regulation of DNA-templated transcription; regulation of growth; and skeletal system development. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb bud; and sensory organ. Orthologous to human TLE5 (TLE family member 5, transcriptional modulator). PHENOTYPE: Mice homozygous for a knock-out allele display altered mating frequency, abnormal pituitary gland growth and development, and varying degrees of postnatal growth retardation leading to premature death among severely runted individuals. [provided by MGI curators] |