| Primary Identifier | MGI:108247 | Organism | mouse, laboratory |
| Chromosome | 10 | NCBI Gene Number | 21665 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables several functions, including SUMO binding activity; protein kinase C binding activity; and transcription coregulator activity. Involved in base-excision repair; epigenetic regulation of gene expression; and regulation of embryonic development. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in PML body. Is expressed in several structures, including epithelium; genitourinary system; nervous system; retina; and skin. Orthologous to human TDG (thymine DNA glycosylase). PHENOTYPE: Mice homozygous for a knock-out allele exhibit lethality during organogenesis, abnormal DNA methylation, and abnormal heart, vascular, and limb development. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
