| Primary Identifier | MGI:1915183 | Organism | mouse, laboratory |
| Chromosome | 10 | NCBI Gene Number | 67933 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables transcription coregulator activity. Involved in regulation of transcription by RNA polymerase II. Acts upstream of or within antiviral innate immune response; immune response involved in response to exogenous dsRNA; and regulation of toll-like receptor 3 signaling pathway. Predicted to be located in cytosol; nuclear body; and plasma membrane. Predicted to be part of MLL1 complex and Set1C/COMPASS complex. Is expressed in central nervous system and retina. Orthologous to human HCFC2 (host cell factor C2). PHENOTYPE: Mice homozygous for null or severely hypomorphic allele exhibit reduced poly(I:C)-mediated TLR3 signaling and increased mortality following viral infection. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
