| Primary Identifier | MGI:1354175 | Organism | mouse, laboratory |
| Chromosome | 10 | NCBI Gene Number | 50493 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables thioredoxin-disulfide reductase (NADPH) activity. Acts upstream of or within cell population proliferation and mesoderm formation. Located in cytosol and nucleus. Is expressed in several structures, including alimentary system; integumental system; musculoskeletal system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Orthologous to human TXNRD1 (thioredoxin reductase 1). PHENOTYPE: Homozygous null mice exhibit early embryonic lethality (by E10.5) and display severe growth retardation and fail to turn. Embryos also exhibit decreased cell proliferation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
