| Primary Identifier | MGI:1917004 | Organism | mouse, laboratory |
| Chromosome | 10 | NCBI Gene Number | 69754 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables protein kinase binding activity. Acts upstream of or within negative regulation of G1/S transition of mitotic cell cycle; negative regulation of cyclin-dependent protein serine/threonine kinase activity; and negative regulation of lymphocyte differentiation. Located in mitochondrion and nucleus. Is expressed in dorsal root ganglion; gallbladder; liver; trigeminal ganglion; and vagus ganglion. Human ortholog(s) of this gene implicated in Parkinson's disease and Parkinson's disease 15. Orthologous to human FBXO7 (F-box protein 7). PHENOTYPE: Homozygotes for a null allele show increased pro-B cell and pro-erythroblast numbers. Homozygotes for a hypomorphic allele show anemia due to a shortened erythrocyte half-life, impaired spermatogenesis, male infertility, altered T cell phenotypes, and increased susceptibility to bacterial infection. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
