Primary Identifier | MGI:3045318 | Organism | mouse, laboratory |
Chromosome | 10 | NCBI Gene Number | 327799 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable cysteine-type deubiquitinase activity. Involved in chromosome segregation; proteasome-mediated ubiquitin-dependent protein catabolic process; and regulation of mitotic cell cycle spindle assembly checkpoint. Located in nucleus. Orthologous to human USP44 (ubiquitin specific peptidase 44). PHENOTYPE: Mice homozygous for a knock-out allele exhibit chromosomal instability, aneuploidy and increased tumor incidence. [provided by MGI curators] |