| Primary Identifier | MGI:1201787 | Organism | mouse, laboratory |
| Chromosome | 10 | NCBI Gene Number | 216233 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables growth hormone receptor binding activity and phosphorylation-dependent protein binding activity. Involved in negative regulation of growth hormone receptor signaling pathway. Acts upstream of or within several processes, including mammary gland development; negative regulation of receptor signaling pathway via JAK-STAT; and positive regulation of neuron differentiation. Predicted to be located in cytoplasm. Predicted to be part of Cul5-RING ubiquitin ligase complex. Is expressed in several structures, including leg; retina; spleen; testis; and ureteric tip. Human ortholog(s) of this gene implicated in endometrial cancer and ovarian carcinoma. Orthologous to human SOCS2 (suppressor of cytokine signaling 2). PHENOTYPE: Mutations in this gene cause accelerated postnatal growth. Homozygotes for a targeted mutation also show increased bone growth, enlargement of most organs, collagen deposition in the skin and some ducts and vessels, lower major urinary protein levels, and elevated IGF-I mRNA levels in some tissues. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
