| Primary Identifier | MGI:109559 | Organism | mouse, laboratory |
| Chromosome | 10 | NCBI Gene Number | 19279 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables protein kinase binding activity and protein tyrosine phosphatase activity. Acts upstream of or within protein dephosphorylation. Predicted to be active in cell junction; cytosol; and plasma membrane. Is expressed in several structures, including central nervous system; dorsal root ganglion; and retina nuclear layer. Orthologous to human PTPRR (protein tyrosine phosphatase receptor type R). PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased ERK1/2 phosphorylation levels in cerebellar Purkinje cells, decreased grip strength, and ataxia characterized by fine motor coordination and balance defects. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
