| Primary Identifier | MGI:1261820 | Organism | mouse, laboratory |
| Chromosome | 10 | NCBI Gene Number | 71902 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable TBP-class protein binding activity. Predicted to be involved in several processes, including SCF complex assembly; positive regulation of RNA polymerase II transcription preinitiation complex assembly; and protein ubiquitination. Predicted to be located in Golgi apparatus; cytosol; and nucleoplasm. Predicted to be part of cullin-RING ubiquitin ligase complex. Predicted to be active in nucleus. Is expressed in several structures, including genitourinary system. Orthologous to human CAND1 (cullin associated and neddylation dissociated 1). PHENOTYPE: Homozygous null mice show prenatal lethality. Heterozygotes show exacerbated transverse aortic constriction (TAC)-induced cardiac hypertrophy and heart failure. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
