| Primary Identifier | MGI:1921164 | Organism | mouse, laboratory |
| Chromosome | 10 | NCBI Gene Number | 73914 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in several processes, including negative regulation of macromolecule metabolic process; regulation of innate immune response; and response to molecule of bacterial origin. Acts upstream of or within interleukin-1-mediated signaling pathway; positive regulation of NF-kappaB transcription factor activity; and protein autophosphorylation. Located in cytoplasm and nucleus. Used to study osteoporosis and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in asthma. Orthologous to human IRAK3 (interleukin 1 receptor associated kinase 3). PHENOTYPE: Mice homozygous for disruptions in this gene display abnormal inflammatory responses to bacterial infections and loose bone mass with age. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
