| Primary Identifier | MGI:3580016 | Organism | mouse, laboratory |
| Chromosome | 10 | NCBI Gene Number | 216439 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable several functions, including GTPase activator activity; kinase regulator activity; and purine ribonucleoside triphosphate binding activity. Acts upstream of or within several processes, including mammary gland alveolus development; positive regulation of mammary gland epithelial cell proliferation; and positive regulation of receptor signaling pathway via JAK-STAT. Is active in glutamatergic synapse and postsynapse. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human AGAP2 (ArfGAP with GTPase domain, ankyrin repeat and PH domain 2). PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired lactation due to abnormal mammary gland growth during lactation, failure of insulin-suppressed gluconeogenesis, and hyperglycemia. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
