Primary Identifier | MGI:1321393 | Organism | mouse, laboratory |
Chromosome | 10 | NCBI Gene Number | 21853 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables identical protein binding activity. Involved in several processes, including DNA damage response; circadian rhythm; and regulation of circadian rhythm. Acts upstream of or within branching morphogenesis of an epithelial tube and lung development. Located in nucleus. Is expressed in several structures, including future brain; genitourinary system; gut; nervous system; and respiratory system. Human ortholog(s) of this gene implicated in advanced sleep phase syndrome and alcohol use disorder. Orthologous to human TIMELESS (timeless circadian regulator). PHENOTYPE: Mice homozygous for a targeted mutation exhibit early embryonic lethality at aprroximately the time of implantation. [provided by MGI curators] |