| Primary Identifier | MGI:1338027 | Organism | mouse, laboratory |
| Chromosome | 10 | NCBI Gene Number | 14561 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable cytokine activity. Involved in positive regulation of SMAD protein signal transduction. Acts upstream of or within several processes, including kidney development; negative regulation of amacrine cell differentiation; and type B pancreatic cell maturation. Located in extracellular space. Is expressed in several structures, including embryo mesenchyme; genitourinary system; limb bud; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in vertebral hypersegmentation and orofacial anomalies. Orthologous to human GDF11 (growth differentiation factor 11). PHENOTYPE: Homozygotes for a null allele die neonatally showing altered patterning of the axial skeleton including abnormal trunk-to-tail transition and ectopic ventral mass with impaired renal, palate, stomach, spleen and pancreatic development. A second null allele alters retinal and olfactory epithelium neurogenesis. A third null allele causes extra thoracic vertebrae. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
