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Protein Coding Gene : Bloc1s1 biogenesis of lysosomal organelles complex-1, subunit 1
Primary Identifier  MGI:1195276 Organism  mouse, laboratory
Chromosome  10 NCBI Gene Number  14533
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Predicted to enable peptide-lysine-N-acetyltransferase activity. Involved in anterograde synaptic vesicle transport. Located in cytosol; early endosome; and mitochondrion. Part of BLOC-1 complex. Is expressed in brain; long bone epiphyseal plate hypertrophic zone; and long bone epiphyseal plate proliferative zone. Orthologous to human BLOC1S1 (biogenesis of lysosomal organelles complex 1 subunit 1).
PHENOTYPE: Homozygous inactivation of this gene leads to embryonic lethality. Mouse embryonic fibroblasts show alterations in autophagy, mitochondrial physiology, and vesicle-mediated transport. [provided by MGI curators]
  • synonyms:
  • GCN5 general control of amino acid synthesis-like 1 (yeast),
  • MGI:2147264,
  • biogenesis of lysosomal organelles complex-1, subunit 1,
  • AI839753,
  • expressed sequence AI839753,
  • Gcn5l1,
  • Bloc1s1,
  • BLOS1
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