Primary Identifier | MGI:1914846 | Organism | mouse, laboratory |
Chromosome | 10 | NCBI Gene Number | 67596 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables phospholipase binding activity. Involved in several processes, including COP9 signalosome assembly; positive regulation of T cell differentiation in thymus; and positive regulation of T cell receptor signaling pathway. Acts upstream of or within TCR signalosome assembly. Located in cytoplasm. Part of TCR signalosome. Is expressed in ductus deferens; testis; thymus; and thymus primordium. Orthologous to human TESPA1 (thymocyte expressed, positive selection associated 1). PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired late thymocyte development. [provided by MGI curators] |