Primary Identifier | MGI:1197517 | Organism | mouse, laboratory |
Chromosome | 11 | NCBI Gene Number | 16886 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables protein kinase activity. Acts upstream of or within several processes, including cornea development in camera-type eye; protein phosphorylation; and spermatogenesis. Located in cis-Golgi network and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and sensory organ. Orthologous to human LIMK2 (LIM domain kinase 2). PHENOTYPE: Male homozygotes for targeted null mutations exhibit small testes but are fertile. Mutant kidneys have fewer glomeruli and dilated renal tubules, but function normally. Mice homozygous for a gene trap allele or spontaneous mutation have open eyelids at birth, corneal abnormalities and inflammation. [provided by MGI curators] |