| Primary Identifier | MGI:1354727 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 29856 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Predicted to enable actin binding activity. Acts upstream of or within negative regulation of systemic arterial blood pressure and positive regulation of cardiac muscle contraction. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be part of filamentous actin. Predicted to be active in microtubule organizing center. Is expressed in alimentary system; bladder wall; limb; and musculature. Orthologous to human SMTN (smoothelin). PHENOTYPE: Mice homozygous for disruptions of both the A and B isoforms of this gene display partial postnatal lethality, impaired intestinal smooth muscle contractility and thus hampered intestinal transit and diverticulosis. Mice lacking only the B isoform appearnormal. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
