| Primary Identifier | MGI:1921772 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 74522 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables histone binding activity. Involved in transposable element silencing by heterochromatin formation. Predicted to be located in cytosol; heterochromatin; and nuclear lumen. Predicted to be active in nucleus. Is expressed in gonad; heart; nervous system; and skeletal muscle. Used to study Charcot-Marie-Tooth disease axonal type 2Z. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2Z. Orthologous to human MORC2 (MORC family CW-type zinc finger 2). PHENOTYPE: Mice homozygous for a null allele exhibit embryonic lethality around E13.5 and decreased embryo size. Mice homozygous for a null allele activated in neurons exhibit increased brain size, altered brain architecture, and behavioral changes. Heterozygosity for the p.S87L mutation is partially prenatal lethal and leads to Charcot-Marie-Tooth disease-like neuropathies. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
