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Protein Coding Gene : Osbp2 oxysterol binding protein 2
Primary Identifier  MGI:1921559 Organism  mouse, laboratory
Chromosome  11 NCBI Gene Number  74309
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Predicted to enable cholesterol binding activity. Acts upstream of or within spermatid development. Located in acrosomal vesicle and apical dendrite. Is expressed in several structures, including central nervous system; genitourinary system; and heart. Orthologous to human OSBP2 (oxysterol binding protein 2).
PHENOTYPE: Mice homozygous for a knock-out allele exhibit male infertility with sperm defects including oligozoospermia, teratozoospermia, asthenozoospermia and abnormal spermiogenesis. [provided by MGI curators]
  • synonyms:
  • gene model 244, (NCBI),
  • oxysterol binding protein 2,
  • RIKEN cDNA C630001G20 gene,
  • Gm244,
  • 1700095P05Rik,
  • MGI:2685090,
  • ORP-4,
  • RIKEN cDNA 1700095P05 gene,
  • OSBPL1,
  • C630001G20Rik,
  • Osbp2
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