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Protein Coding Gene : Thoc5 THO complex 5
Primary Identifier  MGI:1351333 Organism  mouse, laboratory
Chromosome  11 NCBI Gene Number  107829
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Enables mRNA binding activity. Involved in primitive hemopoiesis. Acts upstream of or within several processes, including negative regulation of macrophage differentiation; regulation of mRNA export from nucleus; and regulation of stem cell division. Located in nucleus. Is expressed in early conceptus and inner cell mass. Human ortholog(s) of this gene implicated in breast carcinoma. Orthologous to human THOC5 (THO complex subunit 5).
PHENOTYPE: Mice homozygous for a knock-out allele exhibit embryonic lethality prior to E5.5. [provided by MGI curators]
  • synonyms:
  • RIKEN cDNA 1700060C24 gene,
  • MGC:49541,
  • A430085L24Rik,
  • Fms interacting protein,
  • THO complex 5,
  • Thoc5,
  • 1700060C24Rik,
  • PK1.3,
  • MGI:1920654,
  • MGI:2442522,
  • Fmip,
  • RIKEN cDNA A430085L24 gene
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