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Protein Coding Gene : Znrf3 zinc and ring finger 3
Primary Identifier  MGI:3039616 Organism  mouse, laboratory
Chromosome  11 NCBI Gene Number  407821
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Predicted to enable frizzled binding activity and ubiquitin protein ligase activity. Involved in regulation of Wnt signaling pathway and stem cell proliferation. Predicted to be active in plasma membrane. Is expressed in forelimb mesenchyme; lung; ovary; and skin. Orthologous to human ZNRF3 (zinc and ring finger 3).
PHENOTYPE: Mice homozygous for a targeted allele exhibit complete lethality around birth, aphakia, abnormal lens development and defective enural tube closure in some mice. [provided by MGI curators]
  • synonyms:
  • expressed sequence AA591877,
  • gene model 1167, (NCBI),
  • MGI:3034979,
  • BC019575,
  • zinc and ring finger 3,
  • Gm1167,
  • LOC382477,
  • AA591877,
  • Znrf3,
  • MGI:2686013,
  • cDNA sequence BC019575
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Disease

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