Primary Identifier | MGI:700006 | Organism | mouse, laboratory |
Chromosome | 11 | NCBI Gene Number | 13169 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables actin filament binding activity and protein domain specific binding activity. Involved in neuron projection morphogenesis; podosome assembly; and synapse assembly. Acts upstream of or within Rac protein signal transduction. Located in several cellular components, including lamellipodium; podosome; and ruffle. Is expressed in several structures, including central nervous system; genitourinary system; liver; retina; and spleen. Orthologous to human DBNL (drebrin like). PHENOTYPE: Targeted mutation causes abnormal structure and function in organs including the spleen, heart and lungs. Vesicle transport is impaired in the brain and neurological impairment is observed. [provided by MGI curators] |