Primary Identifier | MGI:107495 | Organism | mouse, laboratory |
Chromosome | 11 | NCBI Gene Number | 17898 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable calcium ion binding activity. Predicted to be involved in cardiac muscle tissue development and heart contraction. Located in dendritic spine. Is expressed in several structures, including gastrocnemius muscle; heart; liver; uterus; and vascular system. Orthologous to human MYL7 (myosin light chain 7). PHENOTYPE: Embryos homozygous for a knock-in allele show lack of atrial myofibrillar organization, atrial malfunction, aberrant cardiac chamber and looping morphogenesis, defects in yolk sac and intraembryonic vasculature, growth arrest, pericardial edema, and death at E10.5-E11.5. [provided by MGI curators] |