| Primary Identifier | MGI:2443012 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 319939 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables guanyl-nucleotide exchange factor adaptor activity. Involved in positive regulation of guanyl-nucleotide exchange factor activity. Acts upstream of or within several processes, including bone resorption; podosome assembly; and regulation of small GTPase mediated signal transduction. Located in podosome. Is expressed in several structures, including craniocervical region bone; foot mesenchyme; reproductive system; spleen primordium; and tail. Orthologous to human TNS3 (tensin 3). PHENOTYPE: Mice homozygous for a null allele exhibit one third postnatal lethality, reduced body weight, growth retardation, smaller digestive tracts with defects in villi and enterocyte differentiation, abnormal lung morphology, and thinner bones with decreased chondrocyte proliferation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
