| Primary Identifier | MGI:1277962 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 15574 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Involved in double-strand break repair via homologous recombination; embryo development; and regulation of protein phosphorylation. Acts upstream of or within DNA damage checkpoint signaling; protein phosphorylation; and response to UV. Predicted to be located in nucleus. Predicted to be part of checkpoint clamp complex. Predicted to be active in site of double-strand break. Is expressed in several structures, including brain; exocrine system; gonad; hemolymphoid system gland; and liver. Orthologous to human HUS1 (HUS1 checkpoint clamp component). PHENOTYPE: Homozygotes for a targeted null mutation exhibit defects in yolk sac vascularization, placental abnormalities, extensive apoptosis, and midgestational lethality. Mutant cells show increased chromosomal abnormalities. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
