| Primary Identifier | MGI:1097668 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 22271 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables deoxyuridine phosphorylase activity; thymidine phosphorylase activity; and uridine phosphorylase activity. Involved in pyrimidine nucleoside monophosphate metabolic process and uridine catabolic process. Acts upstream of or within pyrimidine nucleotide metabolic process and uridine metabolic process. Is active in cytosol. Is expressed in early embryo; extraembryonic ectoderm; nervous system; and sensory organ. Used to study mitochondrial DNA depletion syndrome 1. Orthologous to human UPP1 (uridine phosphorylase 1). PHENOTYPE: Mice homozygous for a targeted disruption have increased uridine concentration in tissues, urine and blood, along with disorders of various nucleotide metabolisms and decreased sensitivity to pentobarbital and 5-fluorouracil. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
