| Primary Identifier | MGI:1342540 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 22778 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and poly-pyrimidine tract binding activity. Involved in negative regulation of DNA-templated transcription. Acts upstream of or within several processes, including hematopoietic or lymphoid organ development; lymphocyte differentiation; and regulation of transcription by RNA polymerase II. Located in nucleus and pericentric heterochromatin. Part of protein-DNA complex. Is expressed in several structures, including brain; hemolymphoid system; lower urinary tract; thymus/parathyroid primordium; and yolk sac. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; acute lymphoblastic leukemia; colorectal cancer; and common variable immunodeficiency 13. Orthologous to human IKZF1 (IKAROS family zinc finger 1). PHENOTYPE: Homozygous mutants have a variety of T, B, and hematopoeitic cell maturation defects. Heterozygotes for one allele exhibit dominant negative effects and mice develop lymphoproliferative disorders. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
