| Primary Identifier | MGI:103232 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 14783 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables insulin receptor binding activity and signaling receptor complex adaptor activity. Involved in several processes, including negative regulation of D-glucose import; negative regulation of signal transduction; and positive regulation of cold-induced thermogenesis. Acts upstream of or within with a negative effect on ERK1 and ERK2 cascade and gene expression. Acts upstream of or within insulin-like growth factor receptor signaling pathway and vascular associated smooth muscle cell migration. Predicted to be located in cytosol. Predicted to be part of protein-containing complex. Is expressed in several structures, including central nervous system; extraembryonic component; genitourinary system; musculoskeletal system; and sensory organ. Orthologous to human GRB10 (growth factor receptor bound protein 10). PHENOTYPE: Maternal transmission of a mutant allele results in both fetal and placental overgrowth. Disproportionate overgrowth of the liver is observed. Paternal transmission of an allele lacking the differentially methylated region results in growth retardation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
