| Primary Identifier | MGI:97450 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 18423 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including brain development; inner ear morphogenesis; and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; embryo ectoderm; genitourinary system; nervous system; and sensory organ. Orthologous to human OTX1 (orthodenticle homeobox 1). PHENOTYPE: Inner ear abnormalities and circling/head-shaking behavior are seen in mild mutants; null mutants also have spontaneous seizures and defects in dorsal telencephalic cortex, mesencephalon, cerebellum and eye; and show delayed growth and sexual maturation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
