| Primary Identifier | MGI:96019 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 15126 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable heme binding activity; oxygen binding activity; and oxygen carrier activity. Predicted to contribute to haptoglobin binding activity and peroxidase activity. Acts upstream of or within erythrocyte maturation and negative regulation of transcription by RNA polymerase II. Predicted to be part of haptoglobin-hemoglobin complex and hemoglobin complex. Is expressed in several structures, including alimentary system; dorsal aorta; extraembryonic component; liver; and placenta. Orthologous to human HBZ (hemoglobin subunit zeta). PHENOTYPE: Mice homozygous for a null allele show background sensitive prenatal lethality, variation in postnatal size and pallor, reduced litter size, and a thalassemia-like picture with anisocytosis, poikilocytosis, polychromasia, reduced mean corpuscular volume and hemoglobin, and increased platelet count. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
