| Primary Identifier | MGI:1351209 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 27140 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including nervous system development; regulation of respiratory gaseous exchange by nervous system process; and respiratory gaseous exchange by respiratory system. Located in nucleus. Is expressed in several structures, including branchial arch; central nervous system; ganglia; genitourinary system; and sensory organ. Used to study congenital central hypoventilation syndrome. Orthologous to human TLX3 (T cell leukemia homeobox 3). PHENOTYPE: Homozygous null mice die within 1 day of birth due to a central respiratory failure that resembles human congenital central hypoventilation syndrome. Mice homozygous for an ENU-induced allele exhibit uncoordinated movements. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
