| Primary Identifier | MGI:1315202 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 20564 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable Roundabout binding activity and heparin binding activity. Involved in aortic valve morphogenesis; atrioventricular valve morphogenesis; and ventricular septum morphogenesis. Acts upstream of or within several processes, including axon guidance; negative regulation of cell population proliferation; and negative regulation of gene expression. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; heart; limb; and sensory organ. Used to study congenital diaphragmatic hernia. Orthologous to human SLIT3 (slit guidance ligand 3). PHENOTYPE: Mice homozygous for a gene trap allele show congenital diaphragmatic hernia (CDH), variable renal defects and enlarged heart right ventricles. Mice homozygous for either of two reporter alleles show diaphragm dysgenesis and die prematurely; those with end-stage CDH show dyspnea and lung congestion. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
