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ncRNA Gene : Mir146 microRNA 146
Primary Identifier  MGI:2676831 Organism  mouse, laboratory
Chromosome  11 NCBI Gene Number  387164
Mgi Type  miRNA gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Acts upstream of or within several processes, including cellular response to estrogen stimulus; cellular response to leukemia inhibitory factor; and cellular response to lipopolysaccharide. Located in synapse. Is expressed in lung. Human ortholog(s) of this gene implicated in atrophic gastritis; carcinoma (multiple); coronary artery disease; fatal familial insomnia; and type 1 diabetes mellitus. Orthologous to human MIR146A (microRNA 146a).
PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased sensitivity to LPS and develop a lympho- and myeloproliferative syndrome. [provided by MGI curators]
  • synonyms:
  • Mirn146,
  • microRNA 146,
  • mmu-mir-146,
  • Mir146,
  • mmu-mir-146a,
  • miR-146a
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