| Primary Identifier | MGI:2385598 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 193116 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable pre-mRNA 3'-splice site binding activity; second spliceosomal transesterification activity; and zinc ion binding activity. Predicted to be involved in cellular response to heat; intracellular protein transport; and mRNA splicing, via spliceosome. Predicted to be located in cytosol and nuclear speck. Predicted to be part of catalytic step 2 spliceosome and small nuclear ribonucleoprotein complex. Is expressed in eye; heart; islets of Langerhans; and lung epithelium. Orthologous to human SLU7 (SLU7 homolog, splicing factor). PHENOTYPE: Mice heterozygous for a knock-out allele exhibit increased sensitivity to chronic (CCl4-induced) and acute (acetaminophen-induced) liver injury, enhanced oxidative stress, and impaired hepatic functions. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
