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Protein Coding Gene : Adra1b adrenergic receptor, alpha 1b
Primary Identifier  MGI:104774 Organism  mouse, laboratory
Chromosome  11 NCBI Gene Number  11548
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Enables alpha1-adrenergic receptor activity. Involved in neuron-glial cell signaling and regulation of blood pressure. Acts upstream of or within several processes, including heart development; positive regulation of blood pressure; and regulation of glycogen catabolic process. Located in membrane. Is expressed in central nervous system; heart; retina; and testis. Orthologous to human ADRA1B (adrenoceptor alpha 1B).
PHENOTYPE: Targeted mutations that inactivate the gene affect atrial contractility and left ventricle function, suggesting their use in modeling chronic heart failure in humans. [provided by MGI curators]
  • synonyms:
  • adrenergic receptor, alpha 1b,
  • MGD-MRK-28066,
  • alpha1B-adrenergic receptor,
  • Adra1b
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Features --> Cross References

Genome

Sequence Feature Displayer

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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

2 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

9 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

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