| Primary Identifier | MGI:101849 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 14694 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables ion channel inhibitor activity. Involved in negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide. Acts upstream of or within pigmentation and translation. Located in cytoplasm; dendrite; and neuronal cell body. Part of small ribosomal subunit. Is expressed in several structures, including central nervous system; genitourinary system; liver; and spleen. Orthologous to human RACK1 (receptor for activated C kinase 1). PHENOTYPE: Embryos homozygous for a hypomorphic allele lack early egg cylinders and die at gastrulation. Heterozygotes show a transient growth deficit, a white belly spot and hypopigmented tail and paws, while embryonic fibroblasts show a reduction in PMA- and insulin-stimulated translation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
