| Primary Identifier | MGI:2384814 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 211007 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable identical protein binding activity and ubiquitin protein ligase activity. Predicted to be involved in several processes, including cellular response to muramyl dipeptide; defense response to symbiont; and positive regulation of type I interferon-mediated signaling pathway. Predicted to be located in nucleolus. Predicted to be active in nuclear body. Orthologous to human TRIM41 (tripartite motif containing 41). PHENOTYPE: Homozygous null mice show impaired innate antiviral response to VSV, Listeria monocytogens, and HSV-1 infection, with decreased survival, increased microbe titers, and decreased cytokine levels. Another null allele shows male infertility with oligozoospermia and male meiosis defects. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
