| Primary Identifier | MGI:107689 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 16568 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Enables intraciliary transport particle B binding activity; microtubule binding activity; and microtubule motor activity. Involved in several processes, including alpha-tubulin acetylation; anterograde dendritic transport of neurotransmitter receptor complex; and microtubule cytoskeleton organization. Acts upstream of or within several processes, including dentate gyrus development; plasma membrane bounded cell projection organization; and regionalization. Located in centriole; motile cilium; and photoreceptor connecting cilium. Part of kinesin II complex. Is active in glutamatergic synapse; non-motile cilium; and postsynapse. Is expressed in several structures, including central nervous system; gonad; node; peripheral nervous system; and utricle epithelium. Used to study dysostosis and polycystic kidney disease. Human ortholog(s) of this gene implicated in allergic disease and asthma. Orthologous to human KIF3A (kinesin family member 3A). PHENOTYPE: Nullizygous mutations result in embryonic lethality, failure to synthesize cilia in the embryonic node, randomization of left-right asymmetry and structural abnormalities of the neural tube, pericardium, branchial arches, and somites. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
