| Primary Identifier | MGI:96557 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 16191 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables cytokine activity. Involved in positive regulation of DNA-binding transcription factor activity; positive regulation of DNA-templated transcription; and positive regulation of immunoglobulin production. Acts upstream of or within positive regulation of peptidyl-tyrosine phosphorylation. Located in extracellular space. Is expressed in colon; thymus; and thymus primordium. Human ortholog(s) of this gene implicated in asthma and stomach cancer. Orthologous to human IL5 (interleukin 5). PHENOTYPE: Homozygotes for a targeted null mutation exhibit loss of normal airway hyperreactivity resulting from aeroallergen challenge, reduced numbers of CD5+ B cells in the peritoneal cavity at 2 weeks, and some altered responses to schistosomiasis infection. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
